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KMID : 0665220190320060678
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Korean Journal of Food and Nutrition
2019 Volume.32 No. 6 p.678 ~ p.686
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The Physicochemical Characteristics and Protective Effect of Hot Water Extracts of Caragana sinica on MIA-induced Osteoarthritis in Rats
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Han Eun-Sook
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Abstract
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The purpose of this study was to examine the physiochemical characteristics of hot water extract of Caragana sinica roots and verified its protective effect on MIA-induced osteoarthritis in rats. The contents of total polyphenol and total flavonoid used in this experiment were 0.40 mg/g and 0.22 mg/g respectively. We found that the weight of all experiment groups which ingested Caragana sinica extract for three weeks evenly increased in rats with MIA-induced osteoarthritis without toxicity in the liver or kidney. In the histopathological test through the Mankin score, the extent of damage of knee joint tissue in the experiment groups to which Caragana sinica extract was administered in 5 mL/kg or 10 mL/kg was significantly lower than that of the negative control groups statistically(p<0.05). As for the grade of osteoarthritis, the extent of tissue damage of the experiment groups to which Caragana sinica extract was administered in 5 mL/kg or 10 mL/kg was lower than that of the negative control groups as well.
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KEYWORD
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Caragana sinica extract, physicochemical characteristics, osteoarthritis histopathological tes
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